Ozempic · Wegovy · Mounjaro · Zepbound
GLP-1 Drugs.
An honest guide.
Roughly 12% of US adults have tried GLP-1 drugs. Most regain weight after stopping. Most lose 25–40% of weight as lean mass without active countermeasures. The cardiovascular benefit is real. The side effects are real. We worked through the literature on every major question and wrote it honestly — not anti-pharma, not pro-pharma, just the data.
Important
If you're currently on a GLP-1: always coordinate any change with your prescribing physician. The articles here are educational scaffolding, not medical advice.
8 cornerstone essays
GLP-1 deep dive
The GLP-1 Side Effects Nobody Mentions in the 30-Second Ad
Beyond nausea and constipation — gastroparesis, ozempic face, vision concerns, mental health effects, pancreatitis. The full side-effect picture and how to manage each.
May 13, 20269 minGLP-1 deep dive
GLP-1 Rebound Weight Prevention: Why Most Regain and How to Be the Exception
Two-thirds regain at one year is the trial-data baseline. Here's the mechanism — leptin set-point defense, ghrelin rebound, lean-mass deficit — and the protocol that consistently produces the better third.
May 12, 20269 minGLP-1 deep dive
Ozempic vs Mounjaro vs Wegovy: An Honest Comparison
Mechanism differences (GLP-1 alone vs dual GLP-1/GIP), trial-data effectiveness, side-effect profiles, cost and access. The choice that actually matters and what's marketing noise.
May 11, 20268 minGLP-1 deep dive
Should I Take Ozempic? An Honest Decision Framework
Who genuinely benefits, who probably shouldn't, what the cost calculus actually looks like, and the lifestyle-first alternative when it works (and when it doesn't).
May 10, 20269 minGLP-1 deep dive
Maintaining Weight After Stopping a GLP-1 (the Real Protocol)
Two-thirds regained at one year is the trial-data baseline. Here's the structural maintenance protocol — appetite recalibration timeline, behavioral scaffolding, and the markers that predict success.
May 9, 20269 minGLP-1 deep dive
What to Eat on a GLP-1: The Protein-Fiber-Fat Priority Protocol
With reduced appetite, you can't waste calories on low-density foods. Here's the priority order — protein first, fiber second, fats third, carbs minimal — plus practical meal structures that hit your targets in small volumes.
May 8, 20269 minGLP-1 deep dive
Preventing Muscle Loss on Ozempic: The Protocol the Trials Implied
25–40% of weight lost on a GLP-1 is lean mass without active countermeasures. Linge 2024 and Jensen 2024 establish what works. Here's the protocol — protein, resistance training, sleep, micronutrients.
May 7, 202611 minGLP-1 deep dive
Transitioning Off Ozempic: A 12-Week Off-Ramp Protocol
Two-thirds of weight regained at one year is the trial-data baseline. Here's the structured 12-week off-ramp that changes the trajectory — taper schedule, protein, strength, sleep.
May 6, 202612 min
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Building or running a GLP-1 off-ramp?
The 4-step Transition Planner gives you a personalized 12-week protocol — protein target, strength schedule, taper guidance — calibrated to your medication and goals.