Glucose Variability · 7 cited studies

Research on Blood Glucose Variability

Continuous glucose monitoring has shifted the conversation from fasting glucose snapshots to dynamic responses. Zeevi 2015 (Cell) found that glycemic response to identical foods varies 2–10× between individuals — a function of microbiome composition, prior meal, sleep, stress, and clinical context. Hall 2018 (PLOS Biology) identified three glucotypes (low/moderate/severe variability) in non-diabetics — many 'normoglycemic' adults frequently spike. Monnier 2006 (JAMA) showed glucose variability generates more oxidative stress than equivalent sustained hyperglycemia. Ceriello's work links postprandial hyperglycemia to cardiovascular events independent of fasting glucose or A1c. The ADA's 2024 Standards of Care recognises CGM as standard for diabetes; emerging value for prediabetes through behaviour change but not yet first-line. Klonoff's 2024 caution on non-diabetic CGM 'lows' is worth holding. Below: the CGM literature.